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Room‐Temperature Swern Oxidations by Using a Microscale Flow System
Author(s) -
Kawaguchi Tatsuya,
Miyata Hiroyuki,
Ataka Kikuo,
Mae Kazuhiro,
Yoshida Junichi
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462466
Subject(s) - swern oxidation , microreactor , microscale chemistry , flow chemistry , chemistry , trifluoroacetic anhydride , exothermic reaction , organic synthesis , organosulfur compounds , organic chemistry , chemical engineering , dimethyl sulfoxide , catalysis , sulfur , mathematics education , mathematics , engineering
Residence time controlled reaction : The Swern oxidation of alcohols has been accomplished by using a microscale flow system, consisting of micromixers and microscale tube reactors (see schematic representation; DMSO=dimethylsulfoxide, TFAA=trifluoroacetic anhydride), at higher temperatures (−20 to 20 °C) than those for conventional macroscale batch systems (−50 °C or below).