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An Exceptionally Selective Lead( II )‐Regulatory Protein from Ralstonia Metallidurans : Development of a Fluorescent Lead( II ) Probe
Author(s) -
Chen Peng,
Greenberg Bill,
Taghavi Safiyh,
Romano Christine,
van der Lelie Daniel,
He Chuan
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462443
Subject(s) - fluorescence , metal ions in aqueous solution , chemistry , ralstonia , lead (geology) , green fluorescent protein , ion , combinatorial chemistry , computational biology , nanotechnology , biophysics , biochemistry , gene , biology , materials science , physics , organic chemistry , optics , paleontology
Lighting up lead : A Pb 2+ ‐regulatory protein from Ralstonia metallidurans has been converted into a highly sensitive fluorescent Pb 2+ probe (PbR691, turquoise circles in scheme). This fluorescent system reveals that the protein exhibits a surprisingly high binding selectivity towards Pb 2+ ions over other metal ions.