Direct Synthesis of an Oligonucleotide–Poly(phenylene ethynylene) Conjugate with a Precise One‐to‐One Molecular Ratio | Zendy

Yang Chaoyong James | Zendy; Pinto Mauricio | Zendy; Schanze Kirk | Zendy; Tan Weihong | Zendy

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Direct Synthesis of an Oligonucleotide–Poly(phenylene ethynylene) Conjugate with a Precise One‐to‐One Molecular Ratio

Author(s) -

Yang Chaoyong James,

Pinto Mauricio,

Schanze Kirk,

Tan Weihong

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200462431

Subject(s) - oligonucleotide , conjugate , conjugated system , polymer , phenylene , biomolecule , materials science , fluorescence , combinatorial chemistry , polymer chemistry , nanotechnology , chemistry , dna , mathematics , physics , mathematical analysis , biochemistry , quantum mechanics , composite material

Polymer probes light up : Amplifying fluorescent polymers conjugated with biomolecules have excellent light‐harvesting and superquenching properties (see scheme). A novel synthetic method is reported for the highly efficient, simple, fast, and readily controllable conjugation of a water‐soluble poly(phenylene ethynylene) with an oligonucleotide.

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