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Direct Synthesis of an Oligonucleotide–Poly(phenylene ethynylene) Conjugate with a Precise One‐to‐One Molecular Ratio
Author(s) -
Yang Chaoyong James,
Pinto Mauricio,
Schanze Kirk,
Tan Weihong
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462431
Subject(s) - oligonucleotide , conjugate , conjugated system , polymer , phenylene , biomolecule , materials science , fluorescence , combinatorial chemistry , polymer chemistry , nanotechnology , chemistry , dna , mathematics , physics , mathematical analysis , biochemistry , quantum mechanics , composite material
Polymer probes light up : Amplifying fluorescent polymers conjugated with biomolecules have excellent light‐harvesting and superquenching properties (see scheme). A novel synthetic method is reported for the highly efficient, simple, fast, and readily controllable conjugation of a water‐soluble poly(phenylene ethynylene) with an oligonucleotide.