Structure and Unique Interactions with DNA of a Cationic  Trans ‐Platinum Complex with the Nonplanar Bicyclic Piperidinopiperidine Ligand | Zendy

Najajreh Yousef | Zendy; Prilutski Dmitri | Zendy; ArdeliTzaraf Yael | Zendy; Perez Jose Manuel | Zendy; Khazanov Elena | Zendy; Barenholz Yechezkel | Zendy; Kasparkova Jana | Zendy; Brabec Viktor | Zendy; Gibson Dan | Zendy

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Structure and Unique Interactions with DNA of a Cationic Trans ‐Platinum Complex with the Nonplanar Bicyclic Piperidinopiperidine Ligand

Author(s) -

Najajreh Yousef,

Prilutski Dmitri,

ArdeliTzaraf Yael,

Perez Jose Manuel,

Khazanov Elena,

Barenholz Yechezkel,

Kasparkova Jana,

Brabec Viktor,

Gibson Dan

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200462389

Subject(s) - cationic polymerization , chemistry , cisplatin , bicyclic molecule , ligand (biochemistry) , stereochemistry , platinum , piperidine , hydrogen bond , dna , ring (chemistry) , molecule , organic chemistry , biochemistry , biology , genetics , receptor , chemotherapy , catalysis

Circumventing cisplatin resistance : The trans ‐[PtCl 2 (NH 3 )(pip‐pip)] + ion (see structure; red Pt, blue N, green Cl, gray C) is a cytotoxic compound with a cationic piperidinopiperidine ligand. The piperidine ring that is removed from the Pt II center is fluxional and acts as a hydrogen‐bond donor. The complex binds calf thymus DNA directly and rapidly ( t 1/2 =11 min) without prior hydrolysis and circumvents cisplatin resistance in ovarian cancer cells.

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