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“Turn ON/OFF your LOV light”: Borondipyrromethene–Flavin Dyads as Biomimetic Switches Derived from the LOV Domain
Author(s) -
Trieflinger Christian,
Rurack Knut,
Daub Jörg
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462377
Subject(s) - flavin group , molecular switch , redox , photochemistry , chemistry , phototropin , turn (biochemistry) , blue light , chromophore , materials science , cryptochrome , optoelectronics , biochemistry , molecule , inorganic chemistry , organic chemistry , circadian clock , gene , enzyme
Molecular lamps : Analogously to a lamp with a light bulb, a switch, and a plug, the fluorescent ON state of dyad 1 can be blocked by other means besides the light switch (“removing the plug”). By using flavin as a redox unit and thermal or UV‐activated thiol/disulfide redox chemistry, one can switch between the oxidized and reduced forms of the dyad (see picture). The reaction is reminiscent of the LOV domains of blue‐light photoreceptors such as the phototropins.