Premium
Consecutive Vinylic to Aryl to Allylic Palladium Migration and Multiple CH Activation Processes
Author(s) -
Zhao Jian,
Campo Marino,
Larock Richard C.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462327
Subject(s) - allylic rearrangement , chemistry , aryl , palladium , medicinal chemistry , alkyl , moiety , stereochemistry , organic chemistry , catalysis
“Through‐space” migration of palladium between remote carbon atoms appears to take place in the generation of π‐allyl–palladium complexes, which are useful intermediates in organic synthesis. The reaction of halogenated arenes with alkynes under Pd‐migration conditions provides the mixture of allylic esters A – C (see reaction shown; X=Br, I; R 1 =H, OMe, CO 2 Et, Cl; R 2 =Ph, t Bu).