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Tetramic Acid Antibiotics: Stereoselective Synthesis of Streptolic Acid and Tirandalydigin
Author(s) -
Iwata Yasuhiro,
Maekawara Naomi,
Tanino Keiji,
Miyashita Masaaki
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462300
Subject(s) - stereoselectivity , antibiotics , chemistry , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , catalysis
A new and promising methodology for the synthesis of the tetramic acid family of antibiotics was developed. The first synthesis of N ‐2,4‐dimethoxybenzyl tirandalydigin ( 1 ), as well as a synthesis of streptolic acid ( 2 ), was achieved in a highly stereoselective manner.