Premium
Reversible Substrate Anchoring: NC‐SPOS as a Sustainable Approach to Solid‐Supported Organic Synthesis
Author(s) -
Porzelle Achim,
Fessner WolfDieter
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462278
Subject(s) - phase (matter) , substrate (aquarium) , diffusion , polymer , organic synthesis , chemistry , chemical engineering , materials science , nanotechnology , combinatorial chemistry , organic chemistry , catalysis , physics , thermodynamics , oceanography , engineering , geology
An on–off relationship : The main problems of conventional solid‐phase organic synthesis (SPOS) are overcome by a freely reversible attachment strategy. Hydrophobic labeling of organic substrates allows noncovalent (NC) binding to hydrophobic carriers in water for solid‐phase‐assisted reactions (“NC‐SPOS”; see scheme). NC‐SPOS reactions are free of the diffusion limitations typical for polymer supports and highly environmentally benign.