Premium
Chasing a Phantom by Total Synthesis: The Butylcycloheptylprodigiosin Case
Author(s) -
Fürstner Alois,
Radkowski Karin,
Peters Hartwig
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462215
Subject(s) - total synthesis , ring (chemistry) , natural product , product (mathematics) , natural (archaeology) , chemistry , stereochemistry , mathematics , organic chemistry , history , geometry , archaeology
The dispute as to whether “butylcycloheptylprodigiosin” is a natural product or solely a misassigned structure lasted for more than a decade. This open question has now been answered by the first total synthesis of this tripyrrole alkaloid (see picture), which makes explicit use of the peculiarities of its highly strained ortho ‐anellated nine‐membered ring.