Practical Synthesis of Enantiopure γ‐Amino Alcohols by Rhodium‐Catalyzed Asymmetric Hydrogenation of β‐Secondary‐Amino Ketones | Zendy

Liu Duan | Zendy; Gao Wenzhong | Zendy; Wang Chunjiang | Zendy; Zhang Xumu | Zendy

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Practical Synthesis of Enantiopure γ‐Amino Alcohols by Rhodium‐Catalyzed Asymmetric Hydrogenation of β‐Secondary‐Amino Ketones

Author(s) -

Liu Duan,

Gao Wenzhong,

Wang Chunjiang,

Zhang Xumu

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200462178

Subject(s) - enantiopure drug , rhodium , chemistry , norbornadiene , ketone , catalysis , organic chemistry , enantioselective synthesis , asymmetric hydrogenation , combinatorial chemistry

Another way to antidepressants : A series of β‐secondary‐amino ketone hydrochlorides (e.g. 1 ) were hydrogenated with remarkably high enantioselectivities by using a Rh complex containing P‐chiral bisphospholane 2 . These results establish a short and practical means for the synthesis of enantiopure N‐monosubstituted γ‐amino alcohols (e.g. 3 ), which are key intermediates in the synthesis of important antidepressants. (nbd=norbornadiene; TON=turnover number).

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