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B 12 ‐ retro ‐Riboswitches: Constitutional Switching of B 12 Coenzymes Induced by Nucleotides
Author(s) -
Gschösser Sigrid,
Gruber Karl,
Kratky Christoph,
Eichmüller Christian,
Kräutler Bernhard
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462085
Subject(s) - nucleotide , conjugate , base (topology) , base pair , chemistry , cofactor , stereochemistry , unit (ring theory) , crystallography , mathematics , biochemistry , dna , gene , enzyme , mathematical analysis , mathematics education
A vitamin that switches states : The appended nucleotide base B assists in the constitutional switch from the base‐on form of the B 12 conjugate (blue, with a coordinated 5,6‐dimethylbenzimidazole (DMB) unit) to the base‐off form (red, with a free DMB unit). The process is strongly temperature dependent.