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Spirocycloisomerization of Tethered Alkylidene Glycocyamidines: Synthesis of a Base Template Common to the Palau'amine Family of Alkaloids
Author(s) -
GarridoHernandez Hugo,
Nakadai Masakazu,
Vimolratana Marc,
Li Qingyi,
Doundoulakis Thomas,
Harran Patrick G.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462069
Subject(s) - amine gas treating , base (topology) , chemistry , combinatorial chemistry , stereochemistry , organic chemistry , mathematics , mathematical analysis
The facile spirocyclization of tethered bisalkylidene 1 suggests a general synthetic strategy for preparing alkaloids of the palau'amine family. The development and characteristics of this core model system are discussed.
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