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Dramatic Rate Enhancement of Asymmetric Phase‐Transfer‐Catalyzed Alkylations
Author(s) -
Shirakawa Seiji,
Yamamoto Kenichiro,
Kitamura Masanori,
Ooi Takashi,
Maruoka Keiji
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462035
Subject(s) - alkylation , catalysis , phase (matter) , ammonium , phase transfer catalyst , chemistry , glycine , polymer chemistry , organic chemistry , amino acid , biochemistry
The intervention of crown ethers or achiral quaternary ammonium salts as achiral phase‐transfer catalysts (PTCs, see scheme) in a chiral PTC system leads to dramatic rate enhancements in the asymmetric alkylation of glycine derivatives.