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Dual Effect of Synthetic Aminoglycosides: Antibacterial Activity against Bacillus anthracis and Inhibition of Anthrax Lethal Factor
Author(s) -
Fridman Micha,
Belakhov Valery,
Lee Lac V.,
Liang FuSen,
Wong ChiHuey,
Baasov Timor
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462003
Subject(s) - bacillus anthracis , microbiology and biotechnology , antibiotics , anthrax toxin , infectious disease (medical specialty) , biology , bacteria , disease , medicine , genetics , pathology , gene , fusion protein , recombinant dna
Defence against bioterrorism : Recent events have created an urgent need for therapeutic strategies to treat anthrax, an infectious disease caused by the toxigenic bacterium Bacillus anthracis. A new class of aminoglycosides (see picture) are powerful inhibitors under physiological conditions of the anthrax lethal factor, which has a major role in the disease, and function simultaneously as antibiotics against B. anthracis.