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Direct, Highly Enantioselective Pyrrolidine Sulfonamide Catalyzed Michael Addition of Aldehydes to Nitrostyrenes
Author(s) -
Wang Wei,
Wang Jian,
Li Hao
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461959
Subject(s) - enantioselective synthesis , pyrrolidine , sulfonamide , chemistry , michael reaction , catalysis , organocatalysis , mannich reaction , organic chemistry , combinatorial chemistry
Just can't get enough : The highly versatile pyrrolidine sulfonamide organocatalyst 1 , which has been used in α‐aminoxylation and Mannich‐type reactions, also mediates diastereo‐ and enantioselective Michael addition reactions of aldehydes and ketones to nitroolefins (see scheme).