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Intermolecular Tandem Pd‐Catalyzed Cross‐Coupling/[4+4] and [4+2] Cycloadditions: A One‐Pot, Five‐Component Assembly of Bicyclo[6.4.0]dodecanes
Author(s) -
Lee Phil Ho,
Lee Kooyeon
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461957
Subject(s) - intermolecular force , cycloaddition , tandem , bicyclic molecule , chemistry , catalysis , component (thermodynamics) , cascade reaction , stereochemistry , coupling reaction , molecule , propargyl , dodecane , combinatorial chemistry , organic chemistry , materials science , physics , composite material , thermodynamics
Starting from α‐bromovinylarenes , propargyl bromides, and dienophiles, a novel intermolecular tandem Pd‐catalyzed cross‐coupling/[4+4] and [4+2] cycloaddition sequence provides bicyclo[6.4.0]dodecane derivatives by a rapid synthesis in one reaction vessel. Five components are assembled into one molecule in this process. EWG=electron‐withdrawing group.