Adjustment of the  γ  Dihedral Angle of an Oligonucleotide P3′→N5′ Phosphoramidate Enhances Its Binding Affinity towards Complementary Strands | Zendy

Obika Satoshi | Zendy; Sekiguchi Mitsuaki | Zendy; Somjing Roongjang | Zendy; Imanishi Takeshi | Zendy

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Adjustment of the γ Dihedral Angle of an Oligonucleotide P3′→N5′ Phosphoramidate Enhances Its Binding Affinity towards Complementary Strands

Author(s) -

Obika Satoshi,

Sekiguchi Mitsuaki,

Somjing Roongjang,

Imanishi Takeshi

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200461942

Subject(s) - phosphoramidate , dihedral angle , chemistry , oligonucleotide , cleavage (geology) , duplex (building) , crystallography , hydrolysis , stereochemistry , biochemistry , materials science , dna , molecule , hydrogen bond , organic chemistry , fracture (geology) , composite material

Bridge to the right angle : A methylene bridge between the C3′ and N5′ atoms restricts the γ dihedral angle of an oligonucleotide P3′→N5′ phosphoramidate within the + sc orientation (see scheme), which improves duplex‐forming ability and accelerates hydrolytic cleavage.

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