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1,2,4‐Oxadiazolidinones as Configurationally Stable Chiral Building Blocks
Author(s) -
Ritter Tobias,
Carreira Erick M.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461934
Subject(s) - simple (philosophy) , variety (cybernetics) , scheme (mathematics) , computer science , protocol (science) , combinatorial chemistry , content (measure theory) , chemistry , mathematics , philosophy , artificial intelligence , epistemology , medicine , mathematical analysis , alternative medicine , pathology
An intriguing scaffold for drug development, 1,2,4‐oxadiazolidinones are obtained in enantiomerically pure form by a simple reaction and purification protocol (see scheme). These heterocycles, including the previously unknown N2‐unsubstituted parent structures, were shown to be configurationally stable under a variety of conditions.

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