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A Fluorous‐Phase Pummerer Cyclative‐Capture Strategy for the Synthesis of Nitrogen Heterocycles
Author(s) -
McAllister Laura A.,
McCormick Rosemary A.,
Brand Stephen,
Procter David J.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461930
Subject(s) - phase (matter) , catalysis , combinatorial chemistry , cleavage (geology) , chemistry , coupling (piping) , throughput , nitrogen , computer science , organic chemistry , materials science , telecommunications , fracture (geology) , metallurgy , composite material , wireless
Catching on : Fluorous‐tagged heterocyclic frameworks accessed rapidly through a Pummerer cyclative‐capture approach can then be modified conveniently, for example, by Pd‐catalyzed cross‐coupling. Traceless, reductive cleavage of the fluorous phase tag completes a strategy for the high‐throughput, fluorous‐phase synthesis of N heterocycles (see scheme, R F =C 8 F 17 CH 2 CH 2 ).