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Convenient Transformation of Optically Active Nitroalkanes into Chiral Aldoximes and Nitriles
Author(s) -
Czekelius Constantin,
Carreira Erick M.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461879
Subject(s) - chemistry , optically active , reagent , combinatorial chemistry , nitro , thiophenol , enantioselective synthesis , organic chemistry , bromide , catalysis , alkyl
An environmentally friendly reaction that excludes the potential contamination of the products by metal impurities is reported. In this reaction, optically active aldoximes and nitriles are prepared from chiral nitroalkanes (see scheme). The methodology described expands the possibilities available for the conversion of nitroalkanes into valuable targets.