Premium
High Relaxivity Confined to a Small Molecular Space: A Metallostar‐Based, Potential MRI Contrast Agent
Author(s) -
Livramento João Bruno,
Tóth Éva,
Sour Angélique,
Borel Alain,
Merbach André E.,
Ruloff Robert
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461875
Subject(s) - contrast (vision) , space (punctuation) , gadolinium , nuclear magnetic resonance , mri contrast agent , magnetic resonance imaging , nanotechnology , materials science , medicine , computer science , radiology , artificial intelligence , physics , operating system , metallurgy
Good things come in small packages : For its moderate molecular weight, the metallostar complex [Fe{Gd 2 L(H 2 O) 4 } 3 ] 4− (see picture; L is a bipyridine–poly(aminocarboxylate) derivative) displays exceptionally high proton relaxivity, which is explained in terms of a rigid supramolecular structure, two inner‐sphere water molecules with a near‐optimal exchange rate, and six efficiently relaxing Gd III centers confined to a small molecular space.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom