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Highly Enantioselective Thiourea‐Catalyzed Nitro‐Mannich Reactions
Author(s) -
Yoon Tehshik P.,
Jacobsen Eric N.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461814
Subject(s) - enantioselective synthesis , thiourea , nitro , catalysis , chemistry , organic chemistry , enantiomer , mannich reaction , combinatorial chemistry , alkyl
Approaching “privileged” status? A new and highly effective enantioselective catalyst for the nitro‐Mannich reaction was identified by modification of thiourea‐based Strecker catalysts (see scheme). Products are obtained in high enantiomeric purity and up to 16:1 diastereoselectivity.