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Strategies for Targeting Protein–Protein Interactions With Synthetic Agents
Author(s) -
Yin Hang,
Hamilton Andrew D.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461786
Subject(s) - small molecule , computational biology , protein–protein interaction , protein design , rational design , chemistry , biology , protein structure , nanotechnology , biochemistry , genetics , materials science
The development of small‐molecule modulators of protein–protein interactions is a formidable goal, albeit one that possesses significant potential for the discovery of novel therapeutics. Despite the daunting challenges, a variety of examples exists for the inhibition of two large protein partners with low‐molecular‐weight ligands. This review discusses the strategies for targeting protein–protein interactions and the state of the art in the rational design of molecules that mimic the structures and functions of their natural targets.