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Developments in Furan Syntheses
Author(s) -
Brown Richard C. D.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461668
Subject(s) - cycloisomerization , furan , dimethylacetamide , chemistry , organic chemistry , combinatorial chemistry , catalysis , solvent
Diversely substituted furans can be prepared from alkynones and alkynoate esters by means of mechanistically novel cycloisomerization and reductive cyclization processes, respectively. Even tetrasubstituted furans can be prepared by cycloisomerization of alkynones, or from allenyl ketones through a Pd‐catalyzed cross‐coupling‐cyclization approach (see scheme; DMA= N , N ‐dimethylacetamide).