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Single‐Triggered Trimeric Prodrugs
Author(s) -
Haba Keren,
Popkov Mikhail,
Shamis Marina,
Lerner Richard A.,
Barbas Carlos F.,
Shabat Doron
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461657
Subject(s) - prodrug , computer science , scheme (mathematics) , chemistry , combinatorial chemistry , computational biology , biochemistry , biology , mathematics , mathematical analysis
The knock‐on effect of a single catalytic reaction by a specific enzyme on a prodrug platform initiates the sequential collapse of the whole array to release the active drug units (see scheme). Such a dendritic system may provide a means to improve selective chemotherapeutic approaches in cancer therapy.