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Head‐to‐Tail Peptide Cyclodimerization by Copper‐Catalyzed Azide–Alkyne Cycloaddition
Author(s) -
Punna Sreenivas,
Kuzelka Jane,
Wang Qian,
Finn M. G.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461656
Subject(s) - alkyne , cycloaddition , azide , copper , chemistry , peptide , polystyrene , catalysis , combinatorial chemistry , oligopeptide , polymer chemistry , organic chemistry , biochemistry , polymer
Rings forged with copper : Oligopeptide cyclodimerization occurs selectively when precursors containing azide and alkyne groups are exposed to copper( I ) ions on polystyrene supports (see picture; Prot =protecting group).
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