Palladium‐Catalyzed Enantioselective Domino Reaction for the Efficient Synthesis of Vitamin E | Zendy

Tietze Lutz F. | Zendy; Sommer Konrad M. | Zendy; Zinngrebe Julia | Zendy; Stecker Florian | Zendy

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Palladium‐Catalyzed Enantioselective Domino Reaction for the Efficient Synthesis of Vitamin E

Author(s) -

Tietze Lutz F.,

Sommer Konrad M.,

Zinngrebe Julia,

Stecker Florian

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200461629

Subject(s) - enantioselective synthesis , palladium , domino , catalysis , yield (engineering) , chemistry , phenol , acrylate , derivative (finance) , cascade reaction , combinatorial chemistry , organic chemistry , materials science , polymer , monomer , economics , financial economics , metallurgy

A new route to vitamin E : The palladium‐catalyzed enantioselective domino reaction of the unsaturated phenol derivative 1 with acrylate provides efficient access to the chiral chroman 2 with 96 % ee and in 84 % yield (see scheme). Intermediate 2 can then be converted into vitamin E in a few steps.

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