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Palladium‐Catalyzed Enantioselective Domino Reaction for the Efficient Synthesis of Vitamin E
Author(s) -
Tietze Lutz F.,
Sommer Konrad M.,
Zinngrebe Julia,
Stecker Florian
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461629
Subject(s) - enantioselective synthesis , palladium , domino , catalysis , yield (engineering) , chemistry , phenol , acrylate , derivative (finance) , cascade reaction , combinatorial chemistry , organic chemistry , materials science , polymer , monomer , economics , financial economics , metallurgy
A new route to vitamin E : The palladium‐catalyzed enantioselective domino reaction of the unsaturated phenol derivative 1 with acrylate provides efficient access to the chiral chroman 2 with 96 % ee and in 84 % yield (see scheme). Intermediate 2 can then be converted into vitamin E in a few steps.