Binol‐Derived Monodentate Phosphites and Phosphoramidites with Phosphorus Stereogenic Centers: Novel Ligands for Transition‐Metal Catalysis | Zendy

Reetz Manfred T. | Zendy; Ma JunAn | Zendy; Goddard Richard | Zendy

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Binol‐Derived Monodentate Phosphites and Phosphoramidites with Phosphorus Stereogenic Centers: Novel Ligands for Transition‐Metal Catalysis

Author(s) -

Reetz Manfred T.,

Ma JunAn,

Goddard Richard

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200461624

Subject(s) - stereocenter , denticity , chemistry , transition metal , olefin fiber , rhodium , catalysis , phosphorus , stereochemistry , medicinal chemistry , metal , combinatorial chemistry , organic chemistry , enantioselective synthesis

Buried in the symmetry : Phosphorylation of ortho ‐substituted binol derivatives leads to monodentate phosphites (X=OR) or phosphoramidites (X=NR 2 ) having stereogenic centers at phosphorus (see scheme). Such compounds are excellent ligands in rhodium‐catalyzed olefin‐hydrogenation (95–99 % ee ) surpassing the C 2 ‐symmetric parent ligands.

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