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Solid‐Phase Synthesis of Styryl Dyes and their Application as Amyloid Sensors
Author(s) -
Li Qian,
Lee JunSeok,
Ha Chanki,
Park Chan Beum,
Yang Guang,
Gan Wen Biao,
Chang YoungTae
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461600
Subject(s) - fluorescence , amyloid (mycology) , amyloid β , chemistry , solid phase synthesis , phase (matter) , combinatorial chemistry , biophysics , nanotechnology , materials science , biochemistry , organic chemistry , pathology , biology , medicine , peptide , optics , inorganic chemistry , physics , disease
The combinatorial approach : A library of fluorescent styryl dyes (320 compounds) was prepared by solid‐phase chemistry. The dyes were screened for their detection of amyloid aggregates, which are associated with diseases such as Alzheimer's, and two of the 320 compounds screened, 2C40 and 2E10, showed promise as brain‐imaging agents (see microscopy image).