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Bromide‐Assisted Oxidation of Substituted Phenols with Hydrogen Peroxide to the Corresponding p ‐Quinol and p ‐Quinol Ethers over WO 4 2− ‐Exchanged Layered Double Hydroxides
Author(s) -
Sels B. F.,
De Vos D. E.,
Jacobs P. A.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461555
Subject(s) - chemistry , tungstate , bromide , hydrogen peroxide , phenols , alkoxy group , medicinal chemistry , organic chemistry , alkyl
A simple and efficient one‐pot synthesis of p ‐quinols and their ethers occurs over tungstate‐exchanged layered double hydroxides (WO 4 2− ‐LDHs), which catalyze the bromide‐assisted oxidation of substituted phenols to the corresponding 4‐alkoxy‐ and 4‐hydroxycyclohexa‐2,5‐dienones in high yields (see scheme).