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Enantioselective Synthesis of Axially Chiral Phthalides through Cationic [Rh I (H 8 ‐binap)]‐Catalyzed Cross Alkyne Cyclotrimerization
Author(s) -
Tanaka Ken,
Nishida Goushi,
Wada Azusa,
Noguchi Keiichi
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461533
Subject(s) - enantioselective synthesis , cationic polymerization , alkyne , binap , chemistry , chirality (physics) , catalysis , benzene , axial symmetry , medicinal chemistry , stereochemistry , polymer chemistry , organic chemistry , physics , chiral symmetry , quantum mechanics , quark , nambu–jona lasinio model
Easy access to axially chiral phthalides that bear one or two oxymethylene functionalities is provided by an enantioselective cross alkyne cyclotrimerization in the presence of the cationic complex [Rh I {( S )‐H 8 ‐binap}] + . The axial chirality is introduced during the formation of the benzene ring with high enantioselectivity.