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The Composition of Ehrlich's Salvarsan: Resolution of a Century‐Old Debate
Author(s) -
Lloyd Nicholas C.,
Morgan Hugh W.,
Nicholson Brian K.,
Ronimus Ron S.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461471
Subject(s) - sodium dithionite , sulfur , chemistry , dithionite , stereochemistry , medicinal chemistry , organic chemistry , enzyme
Elusive molecular structure revealed : The primary components of the historically important pharmaceutical compound salvarsan (arsphenamine, Ehrlich 606) have been shown by ESI mass spectrometry to be cyclopolyarsines [RAs] n (see structure; n =3–6 and R=3‐amino‐4‐hydroxyphenyl).
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