Highly Efficient Dynamic Kinetic Resolution of Azlactones by Urea‐Based Bifunctional Organocatalysts | Zendy

Berkessel Albrecht | Zendy; Cleemann Felix | Zendy; Mukherjee Santanu | Zendy; Müller Thomas N. | Zendy; Lex Johann | Zendy

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Highly Efficient Dynamic Kinetic Resolution of Azlactones by Urea‐Based Bifunctional Organocatalysts

Author(s) -

Berkessel Albrecht,

Cleemann Felix,

Mukherjee Santanu,

Müller Thomas N.,

Lex Johann

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200461442

Subject(s) - bifunctional , thiourea , kinetic resolution , urea , chemistry , amine gas treating , organic chemistry , enantioselective synthesis , catalysis

Novel tasks for a venerable molecule: Bifunctional organocatalysts of the type shown, with a quasi Lewis acidic urea or thiourea unit and a Brønsted basic amine functionality, effect the dynamic kinetic resolution of azlactones with high enantioselectivity. N ‐Benzoyl amino acid esters were obtained with up to 91 % ee in high yields from racemic azlactones.

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