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Catalysts for Cross‐Coupling Reactions with Non‐activated Alkyl Halides
Author(s) -
Frisch Anja C.,
Beller Matthias
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461432
Subject(s) - alkyl , halide , nucleophile , catalysis , chemistry , coupling reaction , coupling (piping) , combinatorial chemistry , organic chemistry , materials science , metallurgy
Despite the problems inherent to metal‐catalyzed cross‐coupling reactions with alkyl halides, these reactions have become increasingly important during the last few years. Detailed mechanistic investigations have led to a variety of novel procedures for the selective cross‐coupling of non‐activated alkyl halides bearing β hydrogen atoms with a variety of organometallic nucleophiles under mild reaction conditions. This Minireview highlights selected examples of metal‐catalyzed coupling methods and is intended to encourage chemists to exploit the potential of these approaches in organic synthesis.