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Highly Compatible Metal and Enzyme Catalysts for Efficient Dynamic Kinetic Resolution of Alcohols at Ambient Temperature
Author(s) -
MartínMatute Belén,
Edin Michaela,
Bogár Krisztián,
Bäckvall JanE.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461416
Subject(s) - kinetic resolution , catalysis , kinetic energy , metal , materials science , chemistry , chemical engineering , organic chemistry , enantioselective synthesis , physics , quantum mechanics , engineering
The combination of highly compatible metal and enzyme catalysts allows the fastest dynamic kinetic resolution of alcohols ever reported. The use of ruthenium catalyst 1 a (or 1 b ) and an immobilized lipase results in a highly efficient enantioselective synthesis of acetates in excellent yields at room temperature (see scheme).