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A DMSO‐Compatible Orienting Medium: Towards the Investigation of the Stereochemistry of Natural Products
Author(s) -
Haberz Peter,
Farjon Jonathan,
Griesinger Christian
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461267
Subject(s) - chemistry , content (measure theory) , natural (archaeology) , stereochemistry , nuclear magnetic resonance spectroscopy , molecule , organic chemistry , mathematics , mathematical analysis , archaeology , history
Organic molecules of different complexity are aligned by a DMSO‐compatible gel in such a way that C–H dipolar couplings up to 29 Hz are observed. This paves the way to the simultaneous determination of conformation and configuration of organic compounds by NMR spectroscopy and thus enables the determination of the stereochemistry of natural products (e.g. hormaomycin, see picture) that cannot be crystallized.