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First Observation of Two Consecutive γ Turns in a Crystalline Linear Dipeptide
Author(s) -
Jiménez Ana I.,
Ballano Gema,
Cativiela Carlos
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461230
Subject(s) - dipeptide , proline , chemistry , solid state , stereochemistry , turn (biochemistry) , crystal structure , crystallography , amino acid , biochemistry
Which way to turn? For the very first time, a linear dipeptide has been shown to accommodate two consecutive γ turns in the solid state. An aminocyclopropane carboxylic acid has overridden the tendency of proline to induce a β‐turn conformation in Pro‐Xaa dipeptides (see X‐ray crystal structure; blue: N, red: O, dashed lines show H bonds).