The Natural Lewis X ‐Bearing Lipids Promote Membrane Adhesion: Influence of Ceramide on Carbohydrate–Carbohydrate Recognition | Zendy

Gourier Christine | Zendy; Pincet Frédéric | Zendy; Perez Eric | Zendy; Zhang Yongmin | Zendy; Zhu Zhenyuan | Zendy; Mallet JeanMaurice | Zendy; Sinaÿ Pierre | Zendy

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The Natural Lewis X ‐Bearing Lipids Promote Membrane Adhesion: Influence of Ceramide on Carbohydrate–Carbohydrate Recognition

Author(s) -

Gourier Christine,

Pincet Frédéric,

Perez Eric,

Zhang Yongmin,

Zhu Zhenyuan,

Mallet JeanMaurice,

Sinaÿ Pierre

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200461224

Subject(s) - ceramide , chemistry , membrane , adhesion , carbohydrate , vesicle , biochemistry , biophysics , biology , organic chemistry , apoptosis

Tight vesicles : Two glycosphingolipids, CerLLe X (see picture) and CerLLe a (Cer=ceramide, L=lactose, Le X =Lewis X determinant, Le a =Lewis a determinant) are used to study the Ca 2+ ‐mediated specific adhesion of natural Le X ‐bearing molecules inserted in fluid bilayer membranes. Vesicle adhesion energy experiments show that Le X –Le X recognition is highly sensitive to molecular structure.

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