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The Natural Lewis X ‐Bearing Lipids Promote Membrane Adhesion: Influence of Ceramide on Carbohydrate–Carbohydrate Recognition
Author(s) -
Gourier Christine,
Pincet Frédéric,
Perez Eric,
Zhang Yongmin,
Zhu Zhenyuan,
Mallet JeanMaurice,
Sinaÿ Pierre
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461224
Subject(s) - ceramide , chemistry , membrane , adhesion , carbohydrate , vesicle , biochemistry , biophysics , biology , organic chemistry , apoptosis
Tight vesicles : Two glycosphingolipids, CerLLe X (see picture) and CerLLe a (Cer=ceramide, L=lactose, Le X =Lewis X determinant, Le a =Lewis a determinant) are used to study the Ca 2+ ‐mediated specific adhesion of natural Le X ‐bearing molecules inserted in fluid bilayer membranes. Vesicle adhesion energy experiments show that Le X –Le X recognition is highly sensitive to molecular structure.