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Novel Three‐Component Reactions Based on a Heck Carbopalladation/Cyclization Domino Reaction
Author(s) -
Kressierer Christoph J.,
Müller Thomas J. J.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461134
Subject(s) - domino , heck reaction , chemistry , aryl , halide , sequence (biology) , component (thermodynamics) , cascade reaction , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis , palladium , physics , biochemistry , alkyl , thermodynamics
In one fell swoop : the reaction of alkynylallyl alcohols with aryl halides in the presence of [Pd(PPh 3 ) 2 Cl 2 ] under Heck reaction conditions provides cyclic γ,δ‐enals (see scheme). This reaction serves as the starting sequence for the one‐pot synthesis of diene esters and β‐amino‐substituted tetrahydrofurans.