An Orthogonal Double‐Linker Resin Facilitates the Efficient Solid‐Phase Synthesis of Complex‐Type N‐Glycopeptide Thioesters Suitable for Native Chemical Ligation | Zendy

Mezzato Stefano | Zendy; Schaffrath Manuela | Zendy; Unverzagt Carlo | Zendy

Premium

An Orthogonal Double‐Linker Resin Facilitates the Efficient Solid‐Phase Synthesis of Complex‐Type N‐Glycopeptide Thioesters Suitable for Native Chemical Ligation

Author(s) -

Mezzato Stefano,

Schaffrath Manuela,

Unverzagt Carlo

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200461125

Subject(s) - linker , ligation , glycopeptide , native chemical ligation , solid phase synthesis , chemical ligation , combinatorial chemistry , amide , chemistry , block (permutation group theory) , rnase p , phase (matter) , computer science , chemical synthesis , biochemistry , amino acid , peptide , organic chemistry , biology , mathematics , programming language , combinatorics , microbiology and biotechnology , rna , gene , in vitro , antibiotics

A safety catch combined with a Rink‐amide linker allowed convenient monitoring (LC–MS) and optimization of several key reactions in a solid‐phase synthesis of the building block A for the glycoprotein RNase B. The native chemical ligation of A and B delivered the glycosylated RNase B fragment 30–68.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research