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Enantioselective Synthesis of Cyclopropanes by Aldehyde Homologation
Author(s) -
Risatti Christina A.,
Taylor Richard E.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200461106
Subject(s) - enantioselective synthesis , aldehyde , chemistry , combinatorial chemistry , stereochemistry , organic chemistry , catalysis
An efficient method for the enantioselective preparation of structurally diverse cyclopropanes has been developed. Sequential homoaldol coupling and activation steps result in a three‐carbon homologation of an aldehyde to give a nonracemic, stereochemically rich cyclopropylcarboxaldehyde (see scheme).