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C 1 ‐Symmetric Sulfoximines as Ligands in Copper‐Catalyzed Asymmetric Mukaiyama‐Type Aldol Reactions
Author(s) -
Langner Martin,
Bolm Carsten
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460953
Subject(s) - oxazoline , aldol reaction , copper , catalysis , chemistry , yield (engineering) , metal , medicinal chemistry , organic chemistry , stereochemistry , polymer chemistry , materials science , metallurgy
Aldol products with quarternary centers have been obtained with up to 99 % ee in high yields by using copper( II ) catalysts bearing C 1 ‐symmetric aminosulfoximines as ligands (see scheme). In terms of ee values and yield the new catalysts compare well with established systems based on metal complexes with bis(oxazoline) and pyridylbis(oxazoline) ligands.