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Dendrimer Folding in Aqueous Media: An Example of Solvent‐Mediated Chirality Switching
Author(s) -
Hofacker Amanda L.,
Parquette Jon R.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460943
Subject(s) - dendrimer , folding (dsp implementation) , aqueous solution , crystallography , chirality (physics) , solvent , chemistry , aqueous medium , conformational change , chemical physics , stereochemistry , polymer chemistry , organic chemistry , physics , chiral symmetry , engineering , quantum mechanics , quark , nambu–jona lasinio model , electrical engineering
Staying in shape: The second and third generations of a new dendron system switch from left‐handed to right‐handed helical conformations upon a change in solvent from THF to water (picture; left). This inversion occurs in tandem with conformational shifts about the OCCO bonds of a subset of terminating glycol chains, from gauche , gauche + , anti to anti , gauche − , anti (picture; right).