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Enantioselective Total Synthesis of the Highly Oxygenated 1,10‐ seco ‐Eudesmanolides Eriolanin and Eriolangin
Author(s) -
Merten Jörn,
Fröhlich Roland,
Metz Peter
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460936
Subject(s) - enantioselective synthesis , chemistry , absolute configuration , total synthesis , stereochemistry , organic chemistry , catalysis
Sultones of swing : A sultone served as the key intermediate in the first enantioselective total syntheses of the bioactive title compounds (see scheme), the absolute configuration of which is now established. Starting from 2‐bromo‐1‐(2‐furyl)ethanone, 24 steps were required to generate the common basic structure, and in each case two additional steps yielded the natural products.