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Vitamin B12 as a Ligand for Technetium and Rhenium Complexes
Author(s) -
Kunze Susanne,
Zobi Fabio,
Kurz Philipp,
Spingler Bernhard,
Alberto Roger
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460923
Subject(s) - rhenium , vitamin b12 , cyanide , technetium , ligand (biochemistry) , chemistry , combinatorial chemistry , inorganic chemistry , nuclear chemistry , biochemistry , receptor
Robust complexes with a central {Co‐CN‐Re(Tc)} feature are formed when the cyanide ligand in vitamin B12 acts as bridging ligand between rhenium and technetium carbonyl complexes (see picture). This concept paves the way for radiolabeling of vitamin B12 or metal‐mediated coupling of bioactive molecules.