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Axial Ligand Effects: Utilization of Chiral Sulfoxide Additives for the Induction of Asymmetry in (Salen)ruthenium (ii) Olefin Cyclopropanation Catalysts
Author(s) -
Miller Jason A.,
Gross Bradley A.,
Zhuravel Michael A.,
Jin Wiechang,
Nguyen SonBinh T.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460887
Subject(s) - cyclopropanation , ruthenium , ethyl diazoacetate , catalysis , olefin fiber , chemistry , ligand (biochemistry) , information asymmetry , combinatorial chemistry , asymmetric induction , enantioselective synthesis , sulfoxide , organic chemistry , business , biochemistry , receptor , finance
An efficient and facile method is used to develop new (salen)ruthenium( II ) catalysts for the asymmetric cyclopropanation of olefins, in which a chiral additive induces asymmetry in inexpensive and readily synthesized achiral (salen)ruthenium( II ) catalysts (see scheme; EDA=ethyl diazoacetate). This approach is amenable to parallel‐screening optimization and has great potential advantages over traditional catalyst development and synthetic methods.