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Biofunctionalization of Fluorescent Rare‐Earth‐Doped Lanthanum Phosphate Colloidal Nanoparticles
Author(s) -
Meiser Felix,
Cortez Christina,
Caruso Frank
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460856
Subject(s) - carbodiimide , lanthanum , conjugated system , nanoparticle , fluorescence , colloid , rare earth , chemistry , amide , avidin , phosphate , doping , combinatorial chemistry , molecule , polymer chemistry , nanotechnology , materials science , inorganic chemistry , organic chemistry , polymer , mineralogy , biotinylation , biochemistry , physics , quantum mechanics , optoelectronics
Approximately eight avidin molecules are conjugated to each Ce/Tb‐doped lanthanum phosphate nanoparticle (NP) through the formation of amide bonds (see scheme). This biofunctionalization process comprises modification of the LaPO 4 NPs with 6‐aminohexanoic acid (AHA) to confer colloidal stability, activation of the AHA carboxy groups by 1‐ethyl‐3‐[3‐dimethylaminopropyl]carbodiimide, and avidin conjugation.
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