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Enantioselective Catalysis with Chiral Phosphine Oxide Preligands
Author(s) -
Dubrovitalia V.,
Börner Armin
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460848
Subject(s) - enantioselective synthesis , phosphine oxide , phosphine , catalysis , oxide , chemistry , phosphorus , homogeneous catalysis , homogeneous , organic chemistry , combinatorial chemistry , physics , thermodynamics
Primed ! Secondary phosphine oxides are able to tautomerize in situ to phosphinous acids and then coordinate to soft transition metals through the trivalent phosphorus atom (see scheme). The presence of a chiral backbone allows this reaction to run stereoselectively and be used for the generation of highly enantioselective homogeneous catalysts.