Premium
Difluoromethyl Phenyl Sulfone, a Difluoromethylidene Equivalent: Use in the Synthesis of 1,1‐Difluoro‐1‐alkenes
Author(s) -
Prakash G. K. Surya,
Hu Jinbo,
Wang Ying,
Olah George A.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460815
Subject(s) - sulfone , chemistry , medicinal chemistry , organic chemistry
A nucleophilic substitution–elimination reaction strategy in which difluoromethyl phenyl sulfone is used as a selective difluoromethylidene equivalent allows the facile synthesis of 1,1‐difluoro‐1‐alkenes from primary alkyl halides (see scheme).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom