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Difluoromethyl Phenyl Sulfone, a Difluoromethylidene Equivalent: Use in the Synthesis of 1,1‐Difluoro‐1‐alkenes
Author(s) -
Prakash G. K. Surya,
Hu Jinbo,
Wang Ying,
Olah George A.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460815
Subject(s) - sulfone , chemistry , medicinal chemistry , organic chemistry
A nucleophilic substitution–elimination reaction strategy in which difluoromethyl phenyl sulfone is used as a selective difluoromethylidene equivalent allows the facile synthesis of 1,1‐difluoro‐1‐alkenes from primary alkyl halides (see scheme).