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A DNA Nanomachine Based on a Duplex–Triplex Transition
Author(s) -
Chen Yi,
Lee SeungHyun,
Mao Chengde
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460789
Subject(s) - dna , duplex (building) , transition (genetics) , chemistry , dna sequencing , a dna , biophysics , component (thermodynamics) , combinatorial chemistry , biochemistry , biology , physics , thermodynamics , gene
Making DNA work : A DNA nanomachine with a mechanism based on a DNA duplex–triplex transition (see figure) was constructed. The key component is a DNA triplex that contains C + GC triplets and is only stable under acidic conditions. The DNA machine uses H + and OH − ions as fuel and its only waste products are H 2 O and NaCl.
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